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GLOSSARY

TSH (Thyroid Stimulating Hormone)

The primary screening test for thyroid function. Elevated TSH indicates hypothyroidism, while low TSH suggests hyperthyroidism.

What is TSH?

Thyroid Stimulating Hormone (TSH) is produced by the pituitary gland in your brain. It tells your thyroid gland how much thyroid hormone to produce. TSH is the most sensitive marker for detecting thyroid dysfunction.

Think of TSH as a thermostat: when thyroid hormone levels are low, TSH rises to stimulate more production. When thyroid hormones are high, TSH drops.

Normal Ranges

StatusTSH Level (mIU/L)
HyperthyroidBelow 0.4
Normal0.4 – 4.0
Subclinical Hypothyroid4.0 – 10.0
HypothyroidAbove 10.0

Note: "Normal" ranges vary by lab and are debated. Many practitioners consider optimal TSH to be 1.0-2.0 mIU/L.

Why It Matters

Metabolism

Your thyroid controls your metabolic rate. Dysfunction can lead to unexplained weight gain or loss, fatigue, and temperature sensitivity.

Energy & Mood

Thyroid hormones affect brain function. Low thyroid is associated with depression, brain fog, and fatigue. High thyroid can cause anxiety and irritability.

Heart Health

Both hypo- and hyperthyroidism affect heart rate and can increase cardiovascular risk if left untreated.

Reproductive Health

Thyroid dysfunction can cause menstrual irregularities, fertility issues, and pregnancy complications.

Symptoms of Thyroid Dysfunction

Hypothyroidism (High TSH)

  • Fatigue and sluggishness
  • Weight gain
  • Cold intolerance
  • Dry skin and hair
  • Constipation
  • Depression

Hyperthyroidism (Low TSH)

  • Anxiety and irritability
  • Weight loss
  • Heat intolerance
  • Rapid heartbeat
  • Tremors
  • Insomnia

Beyond TSH: The Full Thyroid Panel

TSH alone doesn't tell the whole story. Consider testing:

  • Free T4 — The main hormone produced by the thyroid
  • Free T3 — The active form of thyroid hormone
  • Thyroid antibodies — To detect autoimmune thyroid disease (Hashimoto's, Graves')

How Often to Test

  • If healthy with no symptoms: Every 5 years after age 35
  • If you have symptoms: Get tested immediately
  • If on thyroid medication: Every 6-12 weeks when adjusting dose, then annually
  • During pregnancy: Each trimester

Related Biomarkers

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